Minimally Invasive Techniques for Remineralization

Salivary diagnostics have been used to diagnose and monitor systemic disease since the late 1980s when highly sensitive tests were developed to detect hormones and drugs and monitor microbial infections. By the early 2000s, research was initiated to develop a comprehensive catalog of all salivary secretory proteins titled, “Human Salivary Proteome Project.” Most recently, saliva has been examined as a biofluid to identify the presence of SARS-CoV-2, the virus that causes COVID-19. Diagnosing systemic disease is challenging and an invasive approach is often needed. However, salivary diagnostics is a minimally invasive approach to diagnosing and managing oral and systemic disease.