Head and Neck Cancer Cells Hijack Healthy Tissue
University of Michigan School of Dentistry scientists have identified a mechanism by which head and neck cancer cells subvert adjacent normal tissue, allowing small clusters of cancer cells to burrow beneath healthy tissue.
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University of Michigan School of Dentistry scientists have identified a mechanism by which head and neck cancer cells subvert adjacent normal tissue, allowing small clusters of cancer cells to burrow beneath healthy tissue.
The findings, published in the Journal of Experimental Medicine, could lead to new therapeutics that target proteins in cancer cells that regulate DMBT1, a gene that is silenced during oral cancer. Researchers found that when DMBT1 was suppressed in head and neck cancer cells, it promoted aggressive invasion and was associated with metastasis in patients.
From Dimensions of Dental Hygiene. July 2021;19(7):11.
