Reconnecting Practicing Hygienists with the Nation's Leading Educators and Researchers.

Supporting Oral Health Is as Easy as 1, 2, 3

Colgate’s Total Active Prevention System, with innovative stannous fluoride technology, is transforming at-home oral health with synergistic solutions for fighting plaque, gingivitis, and sensitivity.

The management of oral disease has always been a complex endeavor. The presence of multiple pathogens, a wide network of risk factors, and evolving patient needs make designing oral care strategy — before and after dental treatment — a challenging task. Treating oral disease is critical: caries is considered the sixth most common disease worldwide 1 and gingivitis is observed in 90% of the population at some point in their lifetime.2 More important, oral health has been consistently linked to systemic health,3–6 making dental professionals’ efforts even more critical than we previously thought.

Bacteria are the root cause of most common oral problems7,8 and effective oral care agents at home are needed. Lately, a lot of attention has been brought back to stannous fluoride, a classic fluoride agent with several clinically relevant benefits, but also some side effects (mostly staining and metallic taste) and challenging stability in formulation, which made this agent less attractive.

The staining is produced by the stannous ions oxidation. In recent years, numerous advancements have been made to optimize stannous fluoride. These efforts aim to enhance its antibacterial properties while ensuring it remains compatible and synergistic with its remineralization benefits, comparable to sodium fluoride.9,10 Additionally, stannous fluoride provides sensitivity relief,11 protection against erosion,12 and defense against the harmful effects of oral plaque — not only through remineralization but also by targeting the root causes of major oral diseases.

Colgate has conducted years of research that led to a new stannous fluoride toothpaste, Colgate Total Active Prevention. This innovative, patented approach uses phosphates and nitrates to stabilize stannous ions within the formulation. This ensures optimized antibacterial activity, with a high level of bioactive stannous for combating bacteria and fluoride for caries protection, all while effectively minimizing previously mentioned side effects.

This toothpaste significantly reduced bacteria after 4 weeks of use13 12 hours post-brushing compared to a nonantibacterial toothpaste, and effectively reduced gingivitis and plaque build-up at 3 and 6 months of use, compared to a nonantibacterial toothpaste.14 Also, it delivered anti-sensitivity benefits superior to a commercially available potassium nitrate toothpaste.15

Aiming to revolutionize the current approach to oral care, Colgate introduced an Oral Care System that combines a new toothpaste with a CPC+Zn mouthwash and a Colgate Total toothbrush featuring over 5,000 bristles. The toothbrush is designed to enhance foaming and improve the delivery of antibacterial and anti-caries agents.

The clinical evaluation of this new system revealed it is up to 15 times more effective in addressing the root causes of oral health issues such as caries, gingivitis, and bacterial buildup. After 3 weeks of use, 100% of patients reported a healthier mouth compared to a control regimen of nonantibacterial fluoride toothpaste and flat trimmed brush, and by the fourth week, patients experienced a 40% reduction in gingival severity index scores, with 87% reporting a cleaner mouth feel.16

The Colgate Total Active Prevention System, featuring Colgate Total Toothpaste, Toothbrush, and Mouthwash, is designed to work seamlessly together. This synergistic home-care regimen helps patients maintain the oral care plan you recommend in your office — making it as simple as 1, 2, 3.

Colgate oral pharmaceuticals, Inc.
colgateprofessional.com

References

  1. Tonetti MS, Jepsen S, Jin L, Otomo‐Corgel J. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action. J Clin Periodontol. 2017;44:456-462.
  2. Gasner NS, Schure RS. Periodontal Disease. StatPearls. Available at ncbi.nlm.nih.gov/​books/​NBK554590. Accessed December 3, 2024.
  3. Kane SF. The effects of oral health on systemic health. Gen Dent. 2017;65;30-34.
  4. Read E, Curtis MA, Neves JF. The role of oral bacteria in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021; 18:731-742.
  5. Gomes-Filho IS, Passos JS, Seixas da Cruz S. Respiratory disease and the role of oral bacteria. J Oral Microbiol. 2010;2:5811.
  6. Leishman SJ, Lien Do H, Ford PJ. (2010). Cardiovascular disease and the role of oral bacteria. J Oral Microbiol. 2010;2:5781.
  7. Yadav K, Prakash S. Antibiogram profiles against polymicrobial pathogens among dental caries patients at Janaki Medical College teaching hospital, Nepal. Int J Applied Dental Sci. 2015;1: 156-162.
  8. Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nature Reviews Disease Primers. 2017; 3(1):1-14.
  9. Parkinson CR, Milleman KR, Milleman JL. Gingivitis efficacy of a 0.454% w/​w stannous fluoride dentifrice: a 24-week randomized controlled trial. BMC Oral Health. 2020;20:1-8.
  10. Khosravi Y, Palmer S, Daep CA, et al. A commercial SnF2 toothpaste formulation reduces simulated human plaque biofilm in a dynamic typodont model. J Appl Microbiol. 2022; 133;3:1341-1352.
  11. Ayad F, Hetata M, Mateo L, et al. Efficacy of a stannous fluoride toothpaste stabilized with k+ and polyphosphates (SNAP) on immediate tooth sensitivity relief. J Dent Res. 2022; #(101_​B):0512.
  12. O’Toole S, Mistry M, Mutahar M, Moazzez, R, Bartlett D. Sequence of stannous and sodium fluoride solutions to prevent enamel erosion. J Dent. 2015;43:1498-1503.
  13. Deyu H, Li Y, Mateo L, et al. Stannous fluoride vs regular fluoride dentifrice in plaque and gingivitis reduction. J Dent Res. 2022;101_​A:0514.
  14. Hu D, Mateo L, Zhang YP, Stellitano M. Effect of 0.454% stannous fluoride toothpaste on plaque /​gingivitis. J Dent Res. 2023;102_​B:0309.
  15. Ayad F, Hetata M, Mateo L, et al. Efficacy of a stannous fluoride toothpaste stabilized with k+ and polyphosphates (snap) on immediate tooth sensitivity relief. J Dent Res. 2022;101_​B:0512.
  16. Hu D, Mateo, L, D’ambrogio R, Zhang UP, Monty P. Clinical investigation on oral malodor for new formula of stannous toothpaste as compared to Colgate Cavity Protection Toothpaste using organoleptic method. J Dent Res. 2024;103 (Spec Iss A):1167.

From Dimensions of Dental Hygiene. January/February 2025; 23(1):24.

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