Detecting the Signs of Hypophosphatasia

Hypophosphatasia (HPP) is a rare genetic metabolic disorder characterized by a spectrum of defects caused by mutations of the alkaline phosphatase gene that causes the premature loss of dentition. In the absence of trauma, primary tooth exfoliation (with intact roots) occurring prior to the expected exfoliation period should raise suspicion among the extended health care team. Once diagnosed, multidisciplinary collaboration with specialized medical and dental practitioners is important to proper management of HPP. Under such collaborations, appropriate recommendations, anticipatory guidance, follow-up, and management will help ensure the best possible care and clinical outcomes.