Nanofilm Strengthens Dental Pulp and Reduces Inflammation
Nanofilm Strengthens Dental Pulp and Reduces InflammationA dental film engineered using nanotechnology may offer an option for root canal therapy that will preserve the vitality of teeth affected by dental disease without creating a “dead tooth.” Melancortin peptides (? –MSH)
Nanofilm Strengthens Dental Pulp and Reduces Inflammation
A dental film engineered using nanotechnology may offer an option for root canal therapy that will preserve the vitality of teeth affected by dental disease without creating a “dead tooth.” Melancortin peptides (α –MSH) have been found to perform successfully as anti-inflammatory agents in experiments performed on laboratory rats. This development led scientists to test their effect on fibroblasts found in dental pulp.
When the hormone α –MSH was combined with polyglutamic acid (PGA), scientists observed an increase in the number of pulp fibroblasts present in the rats’ dental pulp. The research team, led by Nadia Benkirane-Jessel at the National Institute for Health and Medical Research in Paris, suggests that the combination of the two substances delivered to a cavity site can promote the adhesion and growth of fibroblasts in dental treatment.
The multi-layered film that is coated with α –MSH and PGA is a fraction of the width of a human hair.
Experiments also revealed the combination of α –MSH and PGA has been effective in decreasing inflammation in at least one kind of bacterial infection in pulp fibroblasts, leading scientists to consider the combination as an anti-inflammatory component of treatment for endodontic lesions.
Source: American Chemical Society
