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Perio Update

How PRF Transforms Healing After Extractions

Platelet-rich fibrin (PRF) is redefining post-op recovery by boosting tissue regeneration, reducing complications, and supporting bone growth. Its natural healing power makes it a game-changer for extractions and grafting procedures.

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Platelet-rich fibrin (PRF) is proving to be a powerful ally in dentistry, offering faster healing and fewer complications after extractions. It significantly accelerates both soft and hard tissue healing. The high concentration of platelets and growth factors stimulates cell proliferation, differentiation, and extracellular matrix formation essential for wound healing. Studies indicate that PRF enhances tissue regeneration and accelerates the healing process, leading to quicker recovery times and improved patient comfort.1

One of the primary benefits of PRF in dental extractions is its ability to reduce post-operative pain, swelling, and the risk of complications such as dry sockets. By forming a protective barrier over the wound, PRF maintains the integrity of the blood clot, which is critical for proper healing, and protects the extraction site from bacterial invasion and external irritants.2 PRF is particularly beneficial in cases requiring bone regeneration, such as in patients undergoing bone grafting procedures.

The growth factors in PRF enhance the production of new bone cells, accelerating bone regeneration and ensuring proper healing of the extraction site. This is crucial for maintaining the structural integrity and functionality of the jawbone, especially in preparation for dental implants. PRF also aids in graft stabilization, providing a scaffold for new bone growth and improving the outcomes of grafting procedures.1 With its regenerative properties and ability to enhance patient comfort, PRF is quickly becoming a vital tool in modern dental surgery and implant preparation.

References

  1. Lahham C, Ta’a MA, Lahham E, Michael S, Zarif W. The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues. a randomized controlled trial. BMC Oral Health. 2023;23:677.
  2. Berton F, Costantinides F, Stacchi C, Corradini A, Di Lenarda A, Di Lenarda R. Is LPRF an effective hemostatic agent in single tooth extractions? A cohort study on VKA and DOAC patients. Clin Oral Investig. 2023;27:2865-2874.

This originally appeared in Luan KW, Narvekar A. Unlocking the regenerative power of platelet-rich fibrin. Decisions in Dentistry. 2025;11(2):40-45.

Kevin Luan, BDS, MS, is a clinical assistant professor in the Department of Periodontics at the University of Illinois College of Dentistry in Chicago. He was a Thouron Scholar at the University of Pennsylvania where he completed his residency and master’s degree. Luan is a Diplomate of the American Board of Periodontology and a Health Professions Fellow at Johns Hopkins University School of Education. He can be reached at: kwluan@uic.edu.


Aniruddh Narvekar, BDS, is a clinical assistant professor in the Department of Periodontics at the University of Illinois, College of Dentistry in Chicago. He graduated from the University of Pennsylvania where he completed a dual certificate program in periodontics and periodontal prosthesis. Narvekar is a Diplomate of the American Board of Periodontology.


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