Reconnecting Practicing Hygienists with the Nation's Leading Educators and Researchers.

Novel Approach for Enamel Regeneration

Novel Approach for Enamel Regeneration Once worn away, tooth enamel does not regenerate. And while many research efforts have been directed at creating a material that mimics enamel, no discovery to date has found one that compares with the composition,

Novel Approach for Enamel Regeneration

Once worn away, tooth enamel does not regenerate. And while many research efforts have been directed at creating a material that mimics enamel, no discovery to date has found one that compares with the composition, fracture toughness, and resistance of natural dental enamel. At least until now, with publication of the paper “Matrix Metalloproteinase-20 Mediates Dental Enamel Biomineralization by Preventing Protein Occlusion Inside Apatite Crystals” in the January 2016 issue of Biomaterials.

Genetic mutations in a certain gene (matrix metalloproteinase-20, or MMP-20) result in thin enamel that easily chips off underlying dentin. The absence of this gene, the researchers hypothesized, during amelogenesis results in occlusion of amelogenin in the enamel growth crystals. The results of the study, which was conducted on mice, showed that it is possible—through the mechanism of MMP-20—to prevent unwanted organic materials from trapping enamel crystals that hinder enamel formation. This mechanism, the researchers conclude, may be key to the creation of novel, more effective restorative materials.

Hygiene Connection E-Newsletter

December 2015

Leave A Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy

Dimensions' Discovery EXPO - Get early bird pricing through July 31, 2024!

:
:
:
Coupon has expired

Get Early Bird Pricing!